She is first introduced in Season 4's premiere episode, "Simple Pleasures", and becomes Lip's girlfriend by the end of her maiden season. She was very rude to Lip at first, and tried to put distance between him and Ron, such as when she wouldn't let Lip join their study group because she wanted to keep the group small. She is shown to be rather controlling, and marks Lip and Ron's shared fridge as just Ron's with a decorated message on the door that read "Kuzner only" for some time . However, it is later revealed that she and Ron are merely friends with benefits and that she and Ron only ever had anal sex because she is "saving herself for [her] husband". Amanda became attached to Lip after he started bringing Liam to college with him following Fiona's incarceration and the deterioration of Lip's trust in his sister. Amanda began babysitting Liam during Lip's classes and found Lip's devotion to his siblings an endearing quality. Soon after, Amanda gives Lip a blowjob as he sleeps, and begins to pursue him.
When Lip asked her to help Ian figure out whether or not he liked being with girls, Karen didn't care that she and Ian had just met and was eager to be his test subject. Lip found himself put off by how many guys Karen had been with, and was extremely hurt when Karen revealed that he wasn't the only person who could be the father of her baby. Lip was right to be upset that Karen didn't remain faithful to him when they started developing real feelings for each other, but he shouldn't have been particularly surprised, either.
The next year, , she starred in another short film, Carpool, opposite Morgan Pavey and Andy Dulman. She continued her success in the same year with the indie film, Model Minority, in which Nichole plays the lead role, her first lead role. The film has garnered positive reviews from critics and audiences. The film currently holds a 6.