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The publisher's final edited version of this article is available at Drug Discov Today See other articles in PMC that cite the published article. Abstract Significant progress in understanding the cellular mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis ALS has not been matched with the development of therapeutic strategies to prevent disease progression. The multiple potential causes and relative rarity of the disease are two significant factors that make drug development and assessment in clinical trials extremely difficult. We review recent progress in promoting therapeutics into clinical trials and highlight the value of moderate throughput screening for the acceleration and improvement of drug design.
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ALS is a motor neuron disease , also spelled "motor neurone disease", which is a group of neurological disorders that selectively affect motor neurons , the cells that control voluntary muscles of the body. This form is called "bulbar onset". A few people with ALS have symptoms that are limited to one spinal cord region for at least 12 to 24 months before spreading to a second region; these regional variants of ALS are associated with a better prognosis. Typical or "classical" ALS involves neurons in the brain upper motor neurons and in the spinal cord lower motor neurons.
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Oh, my gosh, yes it was," said Suzie Warmus, destined to become Miss January. It's for Wendy. And to raise money for ALS research. This is a cruel disease. Its cause is unknown.
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